The 2018 HPTN Annual Meeting took place May 15-19 at the Grand Hyatt and The Mayflower in Washington, DC. With a conference theme entitled “The Way Forward”, more than 625 registered participants from 21 countries engaged in a variety of study-specific meetings, Community Working Group sessions and skills-building activities, and scientific plenaries featuring speakers discussing innovative interventions and strategies that will bring us closer to controlling the global HIV epidemic.