Impact of early antiretroviral therapy on the performance of HIV rapid tests and HIV incidence assays
Citation
Fogel JM, Piwowar-Manning E, Debevec B, Walsky T, Schlusser K, Laeyendecker O, Wilson EA, McCauley M, Gamble T, Tegha G, Soko D, Kumwenda J, Hosseinipour MC, Chen YQ, Cohen MS, Eshleman SH. Impact of early antiretroviral therapy on the performance of HIV rapid tests and HIV incidence assays. J Acquir Immune Defic Syndr. 2017, 75: 426-430. PMC5499248
Abstract
BACKGROUND: Antiretroviral therapy (ART) can downregulate antibody responses to HIV infection. We evaluated the impact of early vs. delayed ART on the performance of HIV diagnostic and incidence assays. METHODS: Samples were obtained from 207 participants in the HPTN 052 trial, who were stably suppressed on ART for >/=4 years [Malawi sites; pre-ART CD4 cell count 350-550 cells/mm (early ART arm, N = 180) or